International Journal of Exercise Science 6(3) : 236-241, 2013. The aerobic challenge of marathon running may disrupt the balance of reactive oxygen species (ROS) and endothelial function (EF). Training history may be protective against future risk of cardiovascular disease induced by disruption of ROS balance. In the context of a case study, we measured EF in three subjects using flow mediated dilation (FMD) 3 days before a marathon, within 90 minutes of finishing, and for 2 subsequent days. Subjects were selected based on their training type and history so that a heterogenous sample of athletes was represented. All subjects demonstrated a decline in EF immediately following the marathon (13.7% ± 1.7% to 8.4% ± 2.9%). Recovery of EF was related to aerobic capacity and training history. Marathon training should observe the principle of specificity to maintain ROS balance during physical activity.
Smith, Michael; Hanson, Nicholas; Lucas, Alexander; and Devor, Steven
"Endothelial Response of Running a Marathon: A Tale of Three Runners,"
International Journal of Exercise Science: Vol. 6
Available at: http://digitalcommons.wku.edu/ijes/vol6/iss3/7