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Article Title

COMPARISON OF DIFFERENT LEG PRESS EXERCISE VOLUMES ON THE AKT/MTOR SIGNALING PATHWAY

Abstract

William Hawkins1, Nicole Moodie2, Mallory Matuszek1, Zachary Graham1, John Vardiman1 & Philip Gallagher1

1Applied Physiology Laboratory, University of Kansas, Lawrence, Kansas; 2Rockhurst University, Kansas City, Missouri

PURPOSE: To better understand the types of resistance training protocols that are most beneficial to stimulate muscle hypertrophy, we examined the difference between a single set (SS) of resistance exercise to multiple sets (MS) of resistance exercise on the Akt/mTOR signaling pathway and on the gene expression of insulin-like growth factor-1 (IGF-1) and the receptor for IGF-1 (IGF-1R). METHODS: For this study, sixteen healthy males were divided in to two groups of eight. Subjects in each group received three biopsies: 1) baseline, prior to exercise; 2) 15-minutes post exercise; and 3) 180 minutes post exercise. Subjects in the SS group performed one set of leg press exercise at 80% of their predetermined 1RM to volitional fatigue. Subjects in the MS group performed 2 sets of 10 repetitions and one set to volitional fatigue at 80% of their predetermined 1RM, with 3 minutes of rest between each set. RESULTS: There were no differences between groups in the concentration of Akt signaling proteins. Furthermore, there was no difference in IGF-1 expression. However, there was a greater increase in IGF-1R expression in the SS group compared to the MS group 180 minutes post-exercise. CONCLUSIONS: These data indicate that exercise volume may not alter signals associated protein synthesis in recreationally trained individuals.

(Funded by ACSM Doctoral Research Award)

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