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Article Title

EFFECTS OF IBUPROFEN ON THE PASSIVE PROPERTIES OF MUSCULOTENDINOUS STIFFNESS IN THE PLANTAR FLEXOR MUSCLE GROUP

Abstract

Jake A. Deckert, Catherine A. Hambleton, Trent J. Herda, Eric M. Mosier, Philip M. Gallagher. University of Kansas, Lawrence, Kansas; e-mail: jaked6@ku.edu

Ibuprofen, a non-steroidal anti-inflammatory drug, is one of the most commonly used over the counter drugs. Ibuprofen has been shown increase skeletal muscle hypertrophy/strength while at the same time decreasing measures of delayed onset muscle soreness and inflammation. Ibuprofen has a number of effects on the properties of skeletal muscle, yet few studies have investigated changes musculotendinous stiffness (MTS) resulting from Ibuprofen ingestion. PURPOSE: Therefore, the purpose of this study was to investigate the effects of ibuprofen (IBU) intake on musculotendinous stiffness (MTS) in the plantar flexors. METHODS: 15 participants (age 18-30) completed the study (8 male; 7 female). Subjects visited the lab on two separate occasions. Each visit consisted of two maximum voluntary contractions (MVC) followed by three passive range of motion tests (ROM), on a Biodex System 3 Isokinetic Dynamometer. On the first visit, subjects were given either a placebo or maximum over the counter dose of ibuprofen (1200mg/day) to be ingested in three doses (400mg/dose). Ibuprofen was taken for three days. Multifactorial ANOVA’s were used for all analyses; significance was set at p < .05. RESULTS: There were no significant treatment by time interactions for ROM, MTS, or Torque. No significant individual interactions for time or treatment existed for ROM, MTS, or Torque. There were no significant changes in MVC. CONCLUSION: Ingesting maximal values of Ibuprofen for a 3-day period does not appear to impact MTS and related measures. Given chronic ingestion is commonly recommended by healthcare professionals for maladies from headache to muscle pain to menstrual cramps, it is recommended that future research investigate the impact of chronic ingestion at maximal and supra-maximal doses. With the propensity of tears in the Achilles tendon and other soft tissue in adults who chronically ingest ibuprofen, this research could provide pertinent information as to the mechanism of tendon matrix remodeling as well as a safe timeframe for consumption.

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