Exercise-Induced Improvement in Oxygen Consumption at Ventilatory Threshold is Unaffected by Family History of Diabetes

Authors

Christopher Figueroa, University of Texas at El PasoFollow
Manuel Amador, University of Texas at El PasoFollow
Cesar Meza, The University of Texas at El PasoFollow
Mario Garcia, University of Texas at El PasoFollow
Sudip Bajpeyi, University of Texas at El PasoFollow

Abstract

A family history of type 2 diabetes (FH+) has been reported to increase the risk for insulin resistance. However it is unknown whether a family history of diabetes impairs lipid oxidation capacity. PURPOSE: To investigate if FH impacts lipid oxidation capacity and oxygen consumption at ventilatory threshold (VT). Additionally, we investigated the effects of 8 weeks of combined exercise training on resting lipid oxidation and oxygen consumption at VT in healthy, sedentary, Mexican American males with and without (FH-) a family history of type 2 diabetes. METHODS: 19 sedentary, normoglycemic, Mexican American males underwent 8 weeks of combined exercise training three times per week for 8 weeks (35 minutes of aerobic exercise (60-75% VO_2max) & 45 minutes of resistance exercise). Lipid oxidation was determined using indirect calorimetry. Maximal aerobic capacity (VO_2max, L/min) was measured by respiratory gas exchange during a maximal incremental treadmill exercise test. VT was determined from the VO₂ data collected during the VO_2max test. RESULTS: There were no differences in fasting lipid oxidation measured by RQ at baseline between groups (p=0.44). Exercise training did not change fasting lipid oxidation regardless of FH (mean±SEM: FH- 0.72 ± 0.01 to 0.70 ± 0.20AU; p=0.20; FH+ 0.71 ± 0.01 to 0.72 ± 0.02AU; p=0.33). There were no differences in oxygen consumption at VT between groups at baseline (p=0.82). Following 8 weeks of combined exercise training, both groups improved oxygen uptake at VT (FH-: 1.85 ± 0.06 to 2.12 ± 0.11 L/min; p=0.006; FH+:1.82 ± 0.12 to 2.05 ± 0.13 L/min; p=0.002). FH+ improved VO₂max (3.57 ± 0.16 to 3.82 ± 0.16 L/min; p=0.002), whereas no improvement was observed in FH- (4.08 ± 0.15 to 4.21 ± 0.17 L/min; p=0.16). CONCLUSION: A family history of type 2 diabetes does not impact resting lipid oxidation and oxygen consumption at the ventilatory threshold in a sedentary normoglycemic Mexican American population.

Recommended Citation

Figueroa, Christopher; Amador, Manuel; Meza, Cesar; Garcia, Mario; and Bajpeyi, Sudip (2018) "Exercise-Induced Improvement in Oxygen Consumption at Ventilatory Threshold is Unaffected by Family History of Diabetes," International Journal of Exercise Science: Conference Proceedings: Vol. 2: Iss. 10, Article 57.
Available at: https://digitalcommons.wku.edu/ijesab/vol2/iss10/57