•  
  •  
 

Abstract

Murine models have been used to study the immune response to exercise under various diet and training interventions .Our laboratory has previously studied the effect of forced exercise versus voluntary exercise on fasting blood glucose measurements. However, forced exercise may result in increased corticosterone levels. This may affect glucose levels and subsequent weight gain. Male, wild-type CD-1 mice were randomly divided into the following groups: forced exercise, wheel running, and sedentary. After a 8- weeks of the intervention, all mice were placed on a treadmill and forced to run for 30 minutes. Blood was collected from the mice prior to exercise, immediately following exercise, and one hour post exercise. Plasma corticosterone levels were assessed using an ELISA. 3-color flow cytometry was used to assess blood leukocytes. We found that despite treadmill acclimation in the forced exercise group, there was no significant difference between groups in corticosterone or leukocyte levels when forced to run on a treadmill. All groups showed a spike in corticosterone levels immediately following exercise which returned to baseline at one-hour post.

 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.