ASSOCIATIONS OF INSULIN RESISTANCE WITH METABOLIC SYNDROME RISK FACTORS IN YOUNG, HISPANIC WOMEN
K. Taylor, & C.A. Vella
University of Idaho, Moscow, ID
Approximately 65% of Hispanic women aged 20-39 years are overweight or obese. As Hispanic women age from 12-19 years to 20-39 years the prevalence of overweight and obesity increases from 42% to 65%. Concurrent with this rise in overweight and obesity is an increase in risk of the metabolic syndrome, a precursor to cardiovascular disease. The reasons for this are unknown but may be related to the development of central obesity and insulin resistance in young Hispanic women. PURPOSE: To determine the associations between insulin resistance and metabolic syndrome risk factors in young Hispanic women. METHODS: 131 Hispanic women (mean ± SD: age 25.0 ± 5.0 y; BMI 22.8 ± 3.1 kg·m2; body fat 31.8 ± 6.9 %) participated in the study. Metabolic syndrome risk factors measured were waist circumference, fasting glucose, triglycerides (TG), high-density lipoprotein cholesterol (HDL), and systolic (SBP) and diastolic (DBP) blood pressure. Markers of insulin resistance included homeostasis model assessment (HOMA) and fasting insulin. Pearson product-moment correlation analyses were used to assess associations between variables with alpha level set at 0.05. RESULTS: The majority of participants were normal weight (86%) with only 14% overweight or obese, based on BMI. Prevalence of 1, 2, or 3 or more risk factors was 39%, 14%, and 3%, respectively. Fifty six percent of women had at least one metabolic syndrome risk factor and only 44% were risk factor free. The most prevalent risk factor in this sample was a low HDL with 40% of women exhibiting this risk factor. HOMA and fasting insulin were positively and significantly (p < 0.01) related to waist circumference (r = 0.53 and r = 0.54), TG (r = 0.29 and r =0 .30), SBP (r = 0.25 and r = 0.28) and DBP (r = 0.24 and r = 0.25), respectively, and significantly (p < 0.05) and negatively associated with HDL (r = -0.25 and r = -0.21, respectively). CONCLUSIONS: 56% of women had at least one metabolic syndrome risk factor and 17% had two or more risk factors. HOMA and fasting insulin were associated with individual metabolic syndrome risk factors and may be important clinical markers for identifying Hispanic women at-risk for developing metabolic syndrome. These findings highlight the importance of prevention efforts in normal-weight and overweight young, Hispanic women.
Supported by NIH NIDDK 1SC2DK083061
Taylor, K. and Vella, C.A.
"ASSOCIATIONS OF INSULIN RESISTANCE WITH METABOLIC SYNDROME RISK FACTORS IN YOUNG, HISPANIC WOMEN,"
International Journal of Exercise Science: Conference Proceedings:
1, Article 36.
Available at: http://digitalcommons.wku.edu/ijesab/vol8/iss1/36
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