Reverse Myocardial Remodeling in Hypertrophic Cardiomyopathy: Little Explored Benefit of Exercise

Authors

Jefferson Petto, Bahia Social University Center, Salvador, BA, Brazil; Bahiana School of Medicine and Public Health, Salvador, BA, Brazil; Actus-Cordios, Cardiovascular and Metabolic Rehabilitation, Salvador, BA, Brazil.Follow
Edna C. de Oliveira, Bahia Adventist College, Cachoeira, BA, BrazilFollow
Raissa VA de Almeida, Bahia Adventist College, Cachoeira, BA, BrazilFollow
Alice M. de Oliveira, Bahia Social University Center, Salvador, BA, BrazilFollow
Danielly SN do Amaral, Bahia Adventist College, Cachoeira, BA, Brazil.Follow
Bráulio JB de Pinna Jr., Actus-Cordios, Cardiovascular and Metabolic Rehabilitation, Salvador, BA, BrazilFollow

Other Subject Area

Clinical Exercise Physiology

Abstract

International Journal of Exercise Science 14(2): 1018-1026, 2021. Hypertrophic cardiomyopathy (HCM) is an autosomal dominant disease that causes myocardial remodeling. Physical exercise (PE) is a therapeutic resource used in Supervised Cardiac Rehabilitation (SCR) to improve Quality of Life (QL), reducing cardiovascular morbidity and mortality. Therefore, the aim of this study is to report how SCR using a personalized exercise prescription, promoted Reverse Myocardial Remodeling (RMR), improved functionality and QL of a patient with HCM. This is a case report of a 43-year-old sedentary female patient with a Body Mass Index (BMI) of 24.7 kg/m². The patient was diagnosed with Septal Type Asymmetric HCM. Heart Failure (HF) grade III / IV, according to the New York Heart Association (NYHA), was initially treated with 40mg of Propranolol Hydrochloride twice a day, and presented with excessive fatigue, and angina. The echocardiogram showed a final diastolic volume (FDV) of 130 ml, a final systolic volume (FSV) of 44 ml, a left ventricular mass (LVM) of 236 g, interventricular septum thickness of 14 mm, left ventricular posterior wall (LVPW) thickness of 9 mm, left atrium diameter 46 mm, left ventricular end diastolic diameter of 52mm, septum/left ventricular wall ratio of 1.55 mm, and ejection fraction (EF) of 66% (Teicholz). It was obtained as a result of decreased FDV 130 vs. 102ml, decreased FSV 44 vs. 32 ml, decreased LVM 236 vs. 201 g, increased EF 66 vs. 69%, 26% improvement in QL, and 50% reduction in the dosage of Propranolol Hydrochloride. These results suggest that a personalized SCR program is an adjuvant treatment capable of promoting RMR and improving QL and functionality in a patient with HCM.

Recommended Citation

Petto, Jefferson; de Oliveira, Edna C.; de Almeida, Raissa VA; de Oliveira, Alice M.; do Amaral, Danielly SN; and de Pinna, Bráulio JB Jr. (2021) "Reverse Myocardial Remodeling in Hypertrophic Cardiomyopathy: Little Explored Benefit of Exercise," International Journal of Exercise Science: Vol. 14 : Iss. 2, Pages 1018 - 1026.
DOI: https://doi.org/10.70252/CWHV9788
Available at: https://digitalcommons.wku.edu/ijes/vol14/iss2/12