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EFFECTS OF ANOREXIA NERVOSA ON MUSCLE QUALITY FOLLOWING LONG TERM RECOVERY IN RATS

Abstract

Anorexia nervosa (AN) is physiological and psychological disorder characterized by reduced nutrient intake leading to a decrease in fat and muscle area. A decrease in muscle area increases risk of musculoskeletal injuries and fractures contributing to higher health care costs. There have been limited studies on the long-term effect of AN following weight recovery. PURPOSE: Compare muscle health between simulated AN and subsequent long-term recovery and control rats over a two month recovery period. METHODS: Female Sprauge Dawley rats (age=8 weeks, n=15) underwent simulated AN for 30 days by decreasing their food consumption by ~50-60%. Afterwards, rats were allowed unrestricted access to food, simulating recovery. Ad libitum fed rats served as controls (CON, n=15). Peripheral quantitative computed tomography (PQCT) was used to image muscle cross-sectional area from both CON and AN rats at various recovery time points. Data was analyzed by comparing CON and AN at various time points with pre-planned T-tests. Significance was denoted at p

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