DOES MODERATE INTENSITY EXERCISE ATTENUATE THE POST-PRANDIAL LIPEMIC AND AIRWAY INFLAMMATORY RESPONSE TO A HIGH FAT MEAL?
Stephanie P. Kurti1, Sara K. Rosenkranz2, Stephen K. Chapes3, Morton Levitt4, Brooke J. Cull2, Colby S. Teeman2, Sam R. Emerson2 & Craig A. Harms1, FACSM
1Department of Kinesiology, 2Department of Human Nutrition, 3Department of Biology, Kansas State University, Manhattan, Kansas, 4College of Medicine, Florida Atlantic University, Boca Raton, Florida
Purpose: Recent reports suggest that a single high-fat meal (HFM) leads to increased airway and systemic inflammatory markers and triglycerides. However, an acute bout of exercise in the post prandial period has anti-inflammatory and lipid lowering effects. The purpose of this research was to investigate whether an acute bout of moderate intensity physical activity post-HFM would attenuate post prandial lipemia (PPL) and protect against airway inflammation in active individuals. We hypothesized that an acute bout of exercise would attenuate the increase in PPL and airway inflammation after a HFM. Methods: Twenty healthy, physically active college-aged participants (13M/7F) completed the study. Subjects were required to undergo DEXA scans, pulmonary function testing and performed an incremental exercise test to exhaustion to determine VO2peak.On the second visit, subjects were randomly assigned to a sedentary condition (CON) (n=10, 7M/3F) or moderate-intensity exercise bout (~30-45 min) that expended half of the total calories from the meal (EX; 60% VO2peak) (n=10, 6M/4F) 45 minutes after consuming the HFM (63% fat, 10kcal/kg of bodyweight). Blood lipids and airway inflammation measured via exhaled nitric oxide (eNO) were assessed at baseline, 2 hr and 4 hr post-HFM. Sputum differential cell counts were done to assess airway inflammation at baseline and 4 hr post-HFM. Results: Baseline triglycerides (CON= 66.4 ± 34.7 mg/dL; EX= 58.9 ± 20.5 mg/dL) and eNO (CON= 14.3 ± 5.9 ppb; EX= 18.6 ± 9.84 ppb) were not significantly different between conditions (p>0.05). Triglycerides increased significantly in the CON 2 hr (~54%, p=0.018) and 4 hr (~107%; p=0.018) post-HFM and in the EX condition 2 hr (~66%; p=0.003) and 4 hr (~119%; p=0.004) post-HFM. Exhaled nitric oxide did not significantly increase in the CON 2 hr or 4 hr post-HFM (~17%; p=0.208; ~-2%,p=0.763, respectively) or the EX condition (2 hr= ~10%; p=0.064; 4 hr= ~12%; p=0.167). Percentage of neutrophils and eosinophils significantly increased (pConclusion:These preliminary results indicate an acute bout of moderate intensity exercise does not attenuate postprandial airway inflammation or lipemia following a HFM in physically active subjects. However, a novel finding is that active subjects show pulmonary neutrophilia 4 hours after a high fat meal, independent of increases in exhaled nitric oxide or triglycerides.
Kurti, SP; Rosenkranz, SK; Chapes, SK; Levitt, M; Cull, BJ; Teeman, CS; Emerson, SR; and Harms, CA FACSM
"DOES MODERATE INTENSITY EXERCISE ATTENUATE THE POST-PRANDIAL LIPEMIC AND AIRWAY INFLAMMATORY RESPONSE TO A HIGH FAT MEAL?,"
International Journal of Exercise Science: Conference Proceedings: Vol. 11
, Article 31.
Available at: https://digitalcommons.wku.edu/ijesab/vol11/iss2/31