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EFFECTS OF PLASMA OSMOLALITY ON GLUCOSE REGULATION IN HEALTHY MALES – A PILOT STUDY

Abstract

Lisa T. Jansen, J.D. Adams, Yasuki Sekiguchi, Jillian Fry, Allison Schroeder, Evan C. Johnson, Stavros Kavouras FACSM, University of Arkansas, Fayetteville, Arkansas; e-mail: ltjansen@uark.edu

Poor glucose regulation is the defining characteristic of type II diabetes mellitus (T2DM). Preliminary data from experimental animal have linked dehydration to glucose dysregulation via the action of vasopressin. Also epidemiological data suggest that humans with low water intake are more prone to develop diabetes. PURPOSE: Therefore, the purpose of this study was to investigate the effects of cellular dehydration on glucose regulation in healthy males. METHODS: 4 non-diabetic males (28.4 y±1, HbA1c 5.6±0.2%) were recruited for this preliminary study. Each subject underwent two experimental trials, consisting of a 2 h intravenous infusion of saline (ISO 0.9% and HYP 3.0% of NaCl; 0.1ml∙kg∙min-1 infusion rate), followed by a 2 h oral glucose tolerance test. Blood samples were taken from an antecubital intravenous catheter in 30 min intervals starting at baseline. RESULTS: Mean plasma osmolality was raised to 300±3 mmol/kg for the HYP trial, while ISO maintained a mean of 286± 2 mmol/kg. Glycemic and insulin responses post glucose loading seemed to be delayed but spiked during HYP (150.6 mg/dl glucose at min 60) while displaying a normal response during ISO (136 mg/dl at min 60) trials. HOMA IR: HYP 0.93±0.24 vs. ISO: 0.85± 0.59 and MATSUDA Index: HYP 12.4±5.9 vs. ISO 12.7±6.5 were calculated utilizing glucose and insulin measurements for both trials. HYP seemed to cause increased insulin resistance and decreased insulin sensitivity compared to ISO. CONCLUSION: The present data might indicate the ,kh`` 43-49° C. Based upon their self-reported and measured activity levels and activity types participants were placed into the following groups: aerobically trained (AERO), resistance trained (RES), aerobic and resistance trained (A+R), and sedentary (SED). RESULTS: Total activity differed among the groups with the AERO (203±83 min) and A+R (183±28 min) groups accumulating more physical activity compared to the RES (39±39 min; pCONCLUSIONS: Unlike previous results in middle-aged and older women where higher activity was associated with lower pain sensitivity, our results suggest pain sensitivity does not differ among individuals with differing activity levels in college-aged females. Additionally, we demonstrated pain sensitivity also did not differ among differing types of physical activity.

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