Postprandial and diet-induced chronic inflammation has become a popular point of discussion over recent years in lifestyle medicine as studies have uncovered the effects that various inflammation markers have on chronic diseases including heart disease, diabetes mellitus, and arthritis. Interventions to help lower inflammation could help promote longevity and decrease risk of chronic diseases. PURPOSE: While previous research has shown various effects of fasting on inflammatory biomarkers, this study assessed the impact of an acute 36h fast with or without exercise at the beginning on inflammatory biomarkers (IL-6, C-peptide, GIP, MCP-1, and TNF-alpha). METHODS: Twenty healthy subjects (11 male, 9 female) completed two 36h fasts, with one protocol requiring the subject to complete a treadmill exercise session prior to fasting. Venipuncture was performed every 12 h and samples were later analyzed for inflammatory biomarkers. RESULTS: GIP decreased over the first 12 hours of the fast (pCONCLUSION: Acute fasting reduces GIP, MCP-1 and C-peptide but most of the changes occurred during the first 24 hours of the fast. When exercise was combined with the 36h fast, levels of both C-Peptide and MCP-1 are significantly altered.



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