The autonomic nervous system plays an essential role during exercise by adjusting cardiac output (CO) and redistribution of peripheral blood flows. One primary mechanism responsible for such alterations is the exercise pressor reflex (EPR), a feedback mechanism from contracting muscles via mechano- and metabo-receptor activation. The EPR adjusts the circulation by evoking reflex increases in sympathetic outflow to the heart and the vasculature, eventually increasing blood pressure (BP) during exercise. Previous studies suggested that relative contribution of cardiac and peripheral blood flow to regulate BP may depend on various factors (e.g., sex, health status). Thus, we thought to investigate if one of such factors, such as sex, influences CO, blood flow, and BP responses mediated by metaboreceptor activation. PURPOSE: To determine the role of sex on central and peripheral mechanisms how metaboreceptor-mediated pressor responses are different. METHODS: A total of 16 young adults completed the study. HR from ECG, beat to beat arterial BP from Finapres, and stroke volume (SV) from Modelflow, were continuously measured during baseline, 2 minutes of handgrip exercise at 35% of maximal contraction, 2 minutes of occlusion on exercising arm (postexercise ischemia; PEI), and recovery. Diameter, velocity, and flow of the femoral artery (FBF) were measured using Doppler ultrasound throughout the experiment. CO and TVC were calculated as CO=HR⁢✕SV and TVC=CO/Mean BP, respectively. RESULTS: While both sexes increased mean BP from rest to exercise, men had augmented pressor response (Δ11.1±1.4 men vs. Δ6.1±1.3 women, p

This work is supported by National Institute of Health, National Institute of General Medical Sciences Grant (SC2GM144165 to A.K. Jensen)



To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.