Osteopenia and osteoporosis are a major public health issue in the United States, and current research suggests that moderate to high intensity resistance training is the most effective type of exercise for maintaining bone mineral density (BMD). Sclerostin is a protein secreted by osteocytes which potently inhibits bone formation by binding to the LRP4 in Wnt/β-catenin signaling. BioDensity is a novel resistance training machine that consists of four exercises performed for five seconds each, which applies mechanical loading to the bone and provides a quicker alternative to traditional resistance training. PURPOSE: To examine the effects of 12 weeks of supervised bioDensity training on BMD and sclerostin in young women. METHODS: Nine healthy, young female participants were recruited for the 1-repetition (1-REP) group, and another seven participants were recruited for the 2-repetition (2-REP) group with similar age, weight, height, and ethnicity. They underwent 12 weeks of supervised bioDensity training, once a week. Before and after the intervention, total body composition and BMD at major sites were measured by DXA and serum sclerostin levels were measured in ELISA. Independent sample t-test was used to compare the baseline between groups, and mixed measure ANOVA was used to compare the effects of training within and between groups. RESULTS: We did not find significant time, group, or time x group interaction effects in BMD or serum sclerostin levels after 12-week bioDensity training. There is a large effect size of time (η2 = .214) at lumbar spine BMD after adjusting for height, and medium effect size of time (η2 = .108) in sclerostin levels. No significant differences were found in the percent change of BMD, while the effect size between the two groups was large. CONCLUSION: Although no statistical changes of BMD and sclerostin were observed, the medium to large effect sizes in our pilot study suggest a potential training effect. The bioDensity exercise regimen is feasible and well tolerated in young women.



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