IMPACT OF PHYSICAL ACTIVITY INTERVENTIONS ON PULSE WAVE VELOCITY IN CANCER SURVIVORS: A META-ANALYSIS
Juliette Levet-Bourtayre, Lauren C. Bates-Fraser, Lee Stoner, FACSM, Erik D. Hanson, FACSM. University of North Carolina at Chapel Hill, Chapel Hill, NC.
BACKGROUND: Cancer survivors are living longer, albeit with a decreased health-span as a function of increased cardiovascular disease (CVD) risk. The increased CVD risk is attributable to not only the anti-cancer therapies, but also poor lifestyle behaviors, including physical inactivity. Establishing population-specific physical activity recommendations could mitigate CVD risk and improve health-span. To help facilitate population-specific physical activity guidelines, the objective of this meta-analysis is to determine which physical activity prescription (aerobic, resistance training, or both) decreases CVD risk in cancer survivors (all types) compared to a control (usual care) group. The outcome measure will be pulse wave velocity (PWV), an established measure of biological vascular aging and CVD risk. METHODS: This meta-analysis will be carried out in accordance with PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Following PROSPERO registration, electronic databases will be used to identify articles that meet the criteria: (i) English language, (ii) human studies, (iii) adults (18 years of age and older), (iv) cancer survivors (any type), (v) inclusion of a physical activity intervention (duration of > 20 minutes/session, any type), (vi) inclusion of PWV (carotid-femoral) measurement, (vii) randomized control trial design (includes a control group or wait-list control group). Data will be pooled using the inverse variance heterogeneity model. ANTICIPATED RESULTS: The findings may lead to improvements in physical activity recommendations for cancer survivors that target arterial stiffness and CVD risk. The results of this analysis may also identify gaps in the literature that need to be addressed by further research.
Levet-Bourtayre, J; Bates-Fraser, LC; Stoner, FACSM, L; and Hanson, FACSM, ED
"IMPACT OF PHYSICAL ACTIVITY INTERVENTIONS ON PULSE WAVE VELOCITY IN CANCER SURVIVORS: A META-ANALYSIS,"
International Journal of Exercise Science: Conference Proceedings: Vol. 16:
2, Article 109.
Available at: https://digitalcommons.wku.edu/ijesab/vol16/iss2/109