Melanie S. Semcesen, Alex Pomeroy, Patrick Harrison, Lee Stoner, FACSM. University of North Carolina at Chapel Hill, Chapel Hill, NC.

BACKGROUND: Reduced sleep quality may be associated with an increased risk of cardiovascular disease (CVD). However, there have been mixed results about the nature of the trend in this relationship. To clarify this relationship, we plan to conduct a meta-analysis of the literature surrounding the relationship between sleep quality and CVD risk. Studies that use pulse wave velocity (PWV), the “gold standard” for arterial stiffness measurement and an indicator of CVD risk, will be used to select articles for the meta-analysis. METHODS: Electronic databases (Pubmed and SPORTDiscus) will be referenced from inception to October 2022 with keywords “(sleep) AND (pulse wave velocity OR arterial stiffness).” The search generated 570 results. Studied will be selected from these results based on these criteria: the article must be written in English, the article must contain measures of PWV and sleep quality, pulse wave velocity must be related to sleep quality, and participants must be 18 years or older. Sleep quality measures we expect to find will be taken via subjective methods, such as the Pittsburg Sleep Quality Index (PSQI) or self-reported questionnaires, or via objective methods, such as actigraphy or polysomnography. Random-effects models will be used to calculate weighted mean differences and confidence intervals. EXPECTED RESULTS: Based on previous literature, we are expecting either a linear or a logistic relationship between sleep quality and PWV. If this relationship is found to have a negatively associated logistic trend, this could aid public officials to write guidelines for sleep quality recommendations. In other words, this could tell us if there is a range of declining sleep quality that is with decreased risk before a steep increase in PWV, putting people at higher risk of developing CVD, or if there is a linear relationship between these variables where the lower sleep quality one gets decreases PWV in a linear fashion. Source of funding: NONE

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