Grayson C. Carey, Lauren C. Bates-Fraser, Erik Hanson, FACSM, Lee Stoner, FACSM. University of North Carolina Chapel Hill, Chapel Hill, NC.

BACKGROUND: Endometrial cancer (EC) survivors experience high rates of cardiometabolic comorbidities, such as obesity, and type 2 diabetes that are known risk factors of both EC and cardiovascular disease (CVD). EC survivors are also highly sedentary and engage in very low amounts of physical activity - two major CVD risk factors. EC survivors are 3 times more likely to die of CVD than their cancer. Black endometrial cancer survivors experience a 51% higher risk of overall death are more likely to die of CVD when compared to White women. This racial disparity is multifactorial as it relates to structural racism, endometrial cancer mortality, and long-term survival rates. Investigating sedentary behavior and CVD risk factors in both black and white endometrial cancer survivors may provide insight to the mortality gap impacting these women and indicate potential areas of intervention. METHODS: Endometroid Type 1 EC survivors [(n =≥10 black, n=≥ 10 white), age 50-80, with a BMI greater than 25 kg/m2] will be asked to participate in our cross-sectional study. The primary outcome of this study is carotid-femoral pulse wave velocity (cfPWV) as a measurement of CVD risk. The exposure of interest is sedentary behavior measured via accelerometry and discrimination will be measured as a moderator assessed via the perceived discrimination questionnaire. Participants will also complete the ACT-24, and HRQOL. These data will provide insight into social and environmental factors that may be influencing the overall health of the participants. Statistical procedures will include a linear mixed model with a fixed effect of sedentary behavior and random effects of CVD risk (cfPWV) with race as a moderator. ANTICIPATED RESULTS: We hypothesize that Black EC survivors will have increased cfPWV compared with White EC survivors due to increased CVD risk and structural racism. There is a critical need to identify modifiable CVD risk factors in EC survivors leading to the development of future interventions targeting these behaviors. These data will be used to investigate how perceived discrimination may influence CVD risk and EC’s subsequent activity behaviors.

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