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THE EFFECT OF ACUTE SEDENTARY BEHAVIOR ON REACTIVE OXYGEN SPECIES

NS Kosaraju

Abstract

Nishad Sai Kosaraju. UNC Chapel Hill, Chapel Hill, NC.

The Effect of Acute Sedentary Behavior on Reactive Oxygen Species Nishad Kosaraju1, Alexander Pomeroy1, Erik Hanson FACSM1, Lee Stoner FACSM1 1 University of North Carolina at Chapel Hill, NC, USA. BACKGROUND: Sedentary behaviors, defined as low-intensity behaviors in a seated, reclined, or supine posture, are strongly associated with cardiovascular disease (CVD). While the mechanisms are mostly unknown, sedentary behaviors (e.g., prolonged sitting) may induce pro-inflammatory and impaired immune responses. This exploratory study will (i) determine the reactive oxygen species response to prolonged sitting, and (ii) determine whether sitting interruptions moderate the ROS response. METHODS: A sample size of 56 subjects will be recruited. To be eligible for the study, the participants cannot have any cardiometabolic disorders such as hypertension or hyperlipidemia and must have a BMI under 30 to avoid confounding with obesity. Each subject will complete two conditions, in a random order: CONTROL and MIXED. For CONTROL, the subject will complete 4-hr of uninterrupted sitting. For MIXED, the 4-hr sitting bout will be interrupted with a 15-min standing break or 5-min walking break. A venous blood sample will be collected at the start and end of each condition and used to measure ROS. EXPECTED RESULTS: The findings may elucidate a pathological pathway to target with sitting interruption strategies. Source of funding: This study will be funded by NIH R01HL157187-01A1.

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