Julia Lois Burpeau1, Simon Higgins2, Svetlana Nepocatych1. 1Elon University, Elon, NC. 2University of North Carolina, Chapel Hill, NC.

BACKGROUND: Optimization of lifestyle factors known to positively influence peak bone mass and strength are important in the reduction of risk of osteoporosis and low bone mass in the adult populations. Literature suggests that substantial trabecular bone loss occurs in young adulthood, in conditions of sex steroid sufficiency. However, it is unknown why trabecular bone loss occurs during this time. Trabecular Bone Score (TBS) is used to assess bone quality and identify those who are at risk for bone fractures. During the transition from high school to college, young adults make many lifestyle choices including diet, exercise, and sleep. Therefore, these lifestyle-related factors may help account for changes in TBS. The purpose of the study is to evaluate the changes in physical activity, diet, and sleep duration and changes in TBS in young adults during the transition from high school to college. METHODS: This is a prospective cohort study that will follow high school seniors (n=75 50% female 50% male), ages 17 to 18, who plan to attend a 4-year college within a year of graduating high school. Participants will not be living with their parents or guardians during their first year of study. Participants will be assessed approximately 15 months apart: during their senior year of high school and first year of college. TBS will be measured via dual-energy X-ray absorptiometry (DXA) imaging and analyzed using TBS iNsightTM software. Physical activity and sleep duration will be measured via 3-axis accelerometer (GXT9 Link, ActiGraph), and sedentary behavior via physical activity monitor (activPALTM, PAL Technologies). Dietary intake will be measured with the automated self-administered 24-hour (ASA24) dietary assessment tool. Linear regression will be used to determine the relationship between activity, diet, sleep duration, and TBS while controlling for relevant confounders. ANTICIPATED RESULTS: We anticipate that changes in physical activity, diet, and sleep duration during the transition will be associated with the changes in TBS. In addition, we anticipate that those who are physically active for at least 30 minutes a day, eat within recommended dietary guidelines, and sleep more than 5 hours a night will have higher TBS than those who do not. FUNDING: Funding for this project will be provided by the National Heart, Lung, And Blood Institute of the National Institutes of Health under Award Number R15HL159650.

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