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EXERCISE, BUT NOT WINE, IMPROVES GLYCEMIC CONTROL IN INSULIN-RESISTANT PARTICIPANTS

A Hutt
KA Abraham

Abstract

Ava Hutt, Kirk A. Abraham. Transylvania University, Lexington, KY.

Background: Alcohol increases insulin secretion in response to ingested glucose and exercise enhances insulin sensitivity; therefore, we tested the hypothesis that the combination of wine and exercise would enhance glycemic control in insulin-resistant participants. Methods: Eight participants (6 female, 2 male; 4 with type 2 diabetes, 4 with pre-diabetes) completed four different 1-week treatment periods consisting of no alcohol and no exercise (CON), daily red wine (14 g ethanol) with dinner and no exercise (WINE), no alcohol and daily exercise (60 min at 55% heart rate reserve; EX), or daily wine with dinner and daily exercise (WINE + EX). During the last three days of each treatment period, each participant wore a continuous glucose monitor to record blood glucose data. Results: Average blood glucose levels over each 3-day period were 140 ± 5.9, 139 ± 5.1, 128 ± 5.3, 130 ± 7.4 mg/dl for CON, WINE, EX, and WINE + EX treatments, respectively. Exercise lowered average glucose level (p = 0.01). The percentage of time with blood glucose higher than 130 mg/dl was 62 ± 8.6% for CON, 58 ± 9.8% for WINE, 39 ± 8.6% for EX, and 45 ± 9.2% for WINE + EX, indicating a significant effect of exercise (p < 0.01). Conclusions: These results suggest that one week of exercise lowers both average blood glucose levels and the fraction of time spent above 130 mg/dl in this group of insulin-resistant participants. Daily wine consumption did not affect glycemic control. Supported by Transylvania University.

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