Alec Schumpp1, Jake Dawson1, Lauren Williamson1, Otis Owens1, Kristina Kendall2, James Steele3, Christopher Latella2, Morgan Blake4, Lauren Marcotte5, Carolyn Peddle-McIntyre2, Karen McDonnell1, Ciaran Fairman1. 1University of South Carolina, Columbia, SC. 2Edith Cowan University, Joondalup. 3Solent University, Southampton. 4South College, Knoxville, TN. 5University of British Columbia, Vancouver, BC.

BACKGROUND: Individuals with non-small cell lung cancer (NSCLC) are burdened by long-lasting symptoms post-treatment. These symptoms often reduce physical activity levels and increase the risk of functional decline and development of comorbidities such as cardiovascular disease. Symptom-generated reductions in exercise capacity can lead to exercise avoidance, ultimately resulting in accelerated deconditioning and a poor overall prognosis following treatment. Exercise interventions tailored towards lung cancer survivors should therefore aim to mitigate symptoms impacting exercise capacity (e.g., dyspnea and fatigue). The purpose of this study was to investigate the feasibility and acceptability of a hybrid-delivery home-based cluster-set resistance training program in individuals with NSCLC. METHODS: This study aimed to recruit individuals with NSCLC stage I-III following primary treatments to participate in 8-weeks of home-based resistance training, 3 days per week. The program included supervised sessions in the participants' home and virtual supervision via video conferencing. The primary outcome measure of feasibility was evaluated through retention and intervention fidelity (proportion of exercise completed, relative to what was prescribed). Intervention acceptability was assessed using a 4-point Likert-type scale from “Strongly disagree” to “Strongly agree” to rate the acceptability of intervention components. RESULTS: Fourteen participants were recruited over a 6-month period, with 11 completing the intervention (2 withdrew due to unrelated illness, 1 withdrew due to being on active treatment), yielding a retention rate of 79%. Characteristics of the participants who completed the intervention (n=11) were: 71 ± 10 years; mean BMI 29.1 ± 6.5. Average time (months) since diagnosis was 62 ± 51. Of completers, 27% were male, and 36% were Black, 10 were stage I (91%) and one was stage II (9%). Mean session attendance was 86.4 ± 9.5%. Mean intervention fidelity was 83.1 ± 13.1%. With regards to acceptability, > 90% of participants highly rated all aspects of the intervention delivery (i.e., ease and quality of virtual delivery, level of difficulty, and home-based approach). No adverse events related to exercise were recorded. CONCLUSIONS: The hybrid delivery of a home-based resistance exercise program for individuals previously treated for NSCLC was found to be safe and feasible. Adaptations to the program for future interventions are required, particularly surrounding resistance exercise programming, and intervention delivery with home visits.

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