BACKGROUND: Chemotherapy-Induced Peripheral Neuropathy (CIPN) affects 50-75% of patients who have received chemotherapy, often persisting for years following treatment. In addition to painful and debilitating symptoms, CIPN leads to functional/psychological impairment, increased healthcare spending, and decreased quality of life. CIPN is complex, difficult to diagnose and treat, and poses a heavy burden on patients and providers. Therapies designed to target pain processing and enhance coping such as pain coping skills training (PCST) programs have shown promise for management of pain in various populations, including those with CIPN. However, face to face PCST is underused in healthcare due to high costs, low therapist availability, and transportation requirements. PainTRAINER (an 8-week self guided, cognitive behavioral therapy informed internet-delivered PCST program) was developed to address these barriers. The purpose of this research is to conduct a pilot trial examining the feasibility and acceptability of painTRAINER among patients with CIPN. We also will assess its preliminary efficacy for reducing pain severity and pain interference, as well as the relationship between pain outcomes and spirituality. Though spirituality is known to play an important role in pain management, the use of spirituality practices are underutilized and further study is warranted to direct future pain intervention efforts. METHODS: We will conduct a single group prospective pilot trial with CIPN cancer survivors. Participants (n=26) will complete one 45-minute module per week during the 8-week painTRAINER intervention, learning new cognitive and behavioral pain coping skills each week. Feasibility will be assessed based on ability to recruit, engage, and retain participants; the Acceptability E-Scale will assess acceptability of the intervention following completion. Pain severity and interference (PROMIS measures) and the Brief Multidimensional Measure of Religiousness and Spirituality will be assessed at baseline and post-intervention. ANTICIPATED RESULTS: We hypothesize that painTRAINER will be feasible and acceptable among patients with CIPN, and will demonstrate preliminary efficacy for reducing pain severity and interference. We also hypothesize a positive relationship between spirituality and improvement in pain outcomes, such that higher levels of spirituality will predict greater improvement in pain.

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