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AGE AND PHYSICAL ACTIVITY DOES NOT IMPACT LIPOPOLYSACCHARIDE-BINDING PROTEIN CONCENTRATION IN APPARENTLY HEALTHY ADULTS

Abstract

BACKGROUND: LBP (lipopolysaccharide‐binding protein) is an acute‐phase protein that binds lipopolysaccharide in the blood and plays a role in subsequent activation of immune cells through the production of proinflammatory cytokines. LBP is associated with future cardiovascular disease in middle-aged and older adults. However, there is limited information on the combined influence of aging and physical activity on circulating LBP. Therefore, the purpose of this study was to examine the influence of aging on plasma LBP concentration and the potential influence of physical activity. METHODS: Ten young (4 females, age 23.5 ± 2.2, body mass index 26.3 ± 2.5 blood pressure 120/74 ± 8/8 mmHg) and 11 old (4 female, age 60.7 ± 5.5, body mass index 27.2 ± 3.2, blood pressure 124/74 ± 12/6 mmHg) participated in the study. Physical activity (PA) was assessed using waist worn ActiGraph GT3X accelerometers for a minimum of 6-days (7.1 ± 0.5 days) to obtain average daily steps, sedentary time, and moderate and vigorous PA (MVPA). We measured brachial blood pressure using a SpyghmoCor XCEL after 10-minutes of supine rest. We assessed plasma concentrations of LBP using an enzyme-linked immunosorbent assay kit. Normality was assessed using Shapiro-Wilk. Students’ T Test or Mann Whitney test were used to make age comparisons between young (<35 years) and older (>45 years) adults. Pearson’s correlation, controlled for age, body mass index, and sex, was used to assess relations between MVPA and steps with LBP. Statistical significance was set as p ≤ 0.05 RESULTS: There was not a difference between young and older adults in circulating LBP concentration (young: 8045 ± 3222 vs. older: 8905 ± 7087 pg/ml, p = 0.605). There was not a difference between young and older adults in MVPA (young: 56 ± 30 vs. older: 51 ± 28 min/day, p = 0.748) or average daily steps (young: 8150 ± 4315 vs. older: 8358 ± 4158 steps/day, p = 0.921). There were not associations between LBP and daily MVPA (r = -0.188, p = 0.519) or Steps (r = -0.267, p = 0.356). CONCLUSION: Our preliminary data indicate that there were no age differences in circulating LBP and no associations between habitual physical activity and circulating LBP.

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