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HIGHER BODY FAT PERCENTAGE, FAT MASS, AND TOTAL MASS NEGATIVELY CORRELATED WITH PHYSICAL ACTIVITY AND SLEEP IN ENDOMETRIAL CANCER SURVIVORS

Abstract

BACKGROUND: Obesity is strongly associated with endometrial cancer (EC), with ~60% of EC cases attributed to excess adiposity. Moreover, as rates of obesity increase in the US, EC incidence is expected to continue to rise. Poor 24-hour activity behaviors [24-ABs (moderate-to-vigorous physical activity (MVPA), sedentary behavior (SB), and sleep)] may contribute to obesity rates; however, associations have been inconclusive in EC. Literature reports varying degrees of associations with MVPA/SB and sleep data are limited. Purpose: To investigate the relationship between body composition and 24-ABs in EC survivors. METHODS: Stage 1 ECS, <12 months post-treatment, BMI ≥ 25.0 kg/m2, age 50-80 years, were recruited. Body composition [body fat percentage (%), fat mass (kg), lean mass (kg)] was measured via bioelectrical impedance analysis. 24-ABs were measured for 7 days via accelerometry (MOX). Spearman’s correlation was used to investigate the relationship between body composition and 24-ABs. Descriptive statistics are reported as mean ± standard deviation. RESULTS: Seventeen EC survivors (65% White, 25% Black, 5% Asian, 5% American Indian, 64 ± 7 years old, 6 ± 4 months post-treatment) participated in the study. On average, participants had body fat: 43.4 ± 6.28 %, fat mass: 39.2 ± 13.1 kg, lean mass: 49.5 ± 5.8 kg, MVPA: 173 ± 147 minutes/week, SB: 11.0 ± 4.6 hours/day, sleep: 8.2 ± 1.9 hours/day. There were negative correlations between body fat % and MVPA (rs: -0.514, p= 0.035), fat mass and sleep (rs:-0.574, p= 0.016), lean mass and sleep (rs: -0.485, p= 0.049) and total mass and sleep (rs:-0.572, p= 0.016). Body composition and SB were not correlated. CONCLUSION: There are two key take aways from this preliminary analysis. 1) As hypothesized, higher body fat % was correlated with lower MVPA, this suggests that future interventions should target EC survivors with increased body fat %. 2) Higher fat mass and total mass was correlated with less sleep, as was lean mass although the implications of this latter finding are presently unclear. EC survivors may benefit from sleep interventions that have the potential to decrease as inflammation and may also be more amenable to change than MVPA, but needs to be tested in future intervention.

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