BACKGROUND: The benefits of resistance training (RT) are well established. Many Americans fail to meet the weekly American College of Sports Medicine RT guidelines. Muscle soreness, which commonly follows RT, may contribute to this behavioral trend. Muscle damage from RT results in elevations of circulating myoglobin (MB) and pro-inflammatories interleukin 6 (IL-6) and interleukin 10 (IL-10). While Non-steroidal anti-inflammatory drugs may relieve discomfort associated with RT, they can impair the protein remodeling necessary for muscular improvement. Cannabidiol (CBD), a legal cannabinoid lacking psychotropic effects, is associated with analgesic and anti-inflammatory properties. This has resulted in theories suggesting that CBD supplementation may reduce muscle soreness and enhance recovery following strenuous exercise. However, the benefits of CBD remain inconclusive in humans. The purpose of this study is to determine the impacts of CBD on markers of inflammation, physical performance, and perceived recovery following exhaustive RT. METHODS: Fifteen healthy, recreationally active participants aged 18-45 will be recruited. This double-blind, repeated measure (RM), crossover design has participants perform a damaging squat protocol under a placebo, low dose (2mg/kg), and high dose (10mg/kg) of CBD. The protocol consists of 4 sets of 4-second eccentric back squats loaded with 60% of the participant's weight. The first two sets will be performed until failure with sets three and four matching the repetitions completed from set two. Before and after each protocol, circulating IL-6, IL-10 and MB will be obtained via venipuncture. Performance variables, vertical jump (VJ), perceptual recovery status (PRS), and max bar velocity (MBV), will be collected pre and post (24, 48, & 72hr). Participants will be given a 1-week washout period between each supplementation condition. The effects of CBD will be determined using a 3 (condition) x 4 (time) RM ANOVA model for blood markers, VJ, PRS, and MBV. Measurement outcomes will be correlated with PRS to identify if CBD influences the correlation strength. ANTICIPATED RESULTS: CBD supplementation, of either dose, may reduce markers of inflammation, improve perceived recovery, and protect physical performance from decrements following exhaustive RT. Grant: College of Health and Human Services at Western Kentucky University

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