The Comparison of High-Intensity Interval Exercise vs. Continuous Moderate-Intensity Exercise on C1q/TNF-Related Protein-9 Expression and Flow-Mediated Vasodilation in Obese Individuals

Authors

Brandon G. Fico, University of Texas at AustinFollow
Ryan S. Garten, Virginia Commonwealth University
Michael C. Zourdos, Florida Atlantic University
Michael Whitehurst, Florida Atlantic University
Peter J. Ferrandi, Purdue University
Katelyn M. Dodge, Florida Atlantic University
Gabriel Pena, Florida Atlantic Univerity
Alexandra A. Rodriguez, Florida Atlantic University
Chun-Jung Huang, Florida Atlantic UniversityFollow

Abstract

PURPOSE: A recent novel adipocytokine, C1q/TNF-related protein-9 (CTRP9), has been shown to increase activation of endothelial nitric oxide synthase and reduce vasoconstrictors (e.g., endothelin-1). In addition, CTRP9 may play a compensatory role in obesity-related endothelial dysfunction. Although there is limited information regarding exercise-mediated CTRP9, high-intensity interval exercise (HIIE) has been shown to be as or more effective than continuous moderate-intensity exercise (CME) in improving indicators of endothelial function (e.g., brachial artery flow-mediated dilation [BAFMD]). Therefore, the purpose of this study was to investigate the effect of acute HIIE vs. CME on serum CTRP9 and BAFMD responses in obese individuals. METHODS: Sixteen young male subjects (9 obese and 7 normal-weight) participated in a counterbalanced and caloric equated experiment: HIIE (30 minutes, 4 intervals of 4 minutes at 80-90% of VO_2max with 3 minutes rest between intervals) and CME (38 minutes at 50-60% VO_2max). Serum CTRP9 and BAFMD, were measured prior to, immediately following exercise, and 1 hour and 2 hours into recovery. RESULTS: The concentration of serum CTRP9 was significantly increased immediately following acute HIIE and CME in both obese and normal-weight groups (p = 0.003). Furthermore, both significant treatment by time and group by time interactions for BAFMD were observed following both exercise protocols (p = 0.018; p = 0.009; respectively), with a greater CME-induced BAFMD response at 2 hours into recovery in obese compared to normal-weight subjects. Additionally, a positive correlation in percent change (baseline to peak value) between CTRP9 and BAFMD was found following acute CME (r = 0.589, p = 0.016). CONCLUSIONS: Acute HIIE is as effective as CME to upregulate CTRP9 expression in both obese and normal-weight individuals, although CTRP9 may potentially improve CME-mediated BAFMD. The novel results from this study provide a foundation for additional examination of the mechanisms of exercise-mediated CTRP9 on endothelial function.

Recommended Citation

Fico, Brandon G.; Garten, Ryan S.; Zourdos, Michael C.; Whitehurst, Michael; Ferrandi, Peter J.; Dodge, Katelyn M.; Pena, Gabriel; Rodriguez, Alexandra A.; and Huang, Chun-Jung (2018) "The Comparison of High-Intensity Interval Exercise vs. Continuous Moderate-Intensity Exercise on C1q/TNF-Related Protein-9 Expression and Flow-Mediated Vasodilation in Obese Individuals," International Journal of Exercise Science: Conference Proceedings: Vol. 2: Iss. 10, Article 1.
Available at: https://digitalcommons.wku.edu/ijesab/vol2/iss10/1