A family history of type 2 diabetes (FH+) is considered a risk factor for insulin resistance and poor cardiorespiratory fitness. However, it is not known if a FH+ impedes exercise-induced improvements in maximal aerobic capacity (VO2max). Purpose: The purpose of this study was to determine if normoglycemic, sedentary, Hispanic men with FH+ have a lower VO2max compared to those without a family history of type 2 diabetes (FH-) and if the improvement in VO2max after 8-weeks of combined exercise training is comparable between FH- and FH+. Methods: 20 participants underwent 8 weeks of combined exercise training (35 min aerobic at 60-75% VO₂max followed by 6 full-body resistance exercises) 3x/week. VO₂max was measured using ParvoMedics 2400 metabolic measurement system during a standardized graded exercise test performed on a treadmill. Body composition was assessed by dual-energy x-ray absorptiometry. Results: There was no difference in VO2max at baseline regardless of family history (3.57 ± 1.7 vs. 3.91 ± 0.21 L/min; p=0.22). Eight weeks of combined exercise training significantly improved VO₂max (3.57 ± 0.17 to 3.82 ± 0.16 L/min; p=0.002) in FH+, and tended to increase VO2max in FH- (3.91 ± 0.21 to 4.06 ± 0.21 L/min; p=0.09). There was no difference in VO2max between groups after 8 weeks of exercise training (p=0.67). Lean body mass significantly improved in both groups (FH+ 50.7 ± 1.7 to 53.5 ± 1.79 kg; pConclusions: A family history of diabetes shows no effect on cardiorespiratory fitness in a normoglycemic, sedentary, Mexican American population.



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