Metabolic and Vascular Responses to Short, Disrupted Sleep and High-Intensity Interval Exercise in Healthy Men

Authors

Matthew Peterson, Baylor UniversityFollow
Zacharias Papadakis, Rice UniversityFollow
Jeffrey S. Forsse, Stephen F. Austin State UniversityFollow
Fernando Gutierrez, Baylor UniversityFollow
Taylor Kyle, Auburn University - MontgomeryFollow
Peter GrandjeanFollow

Abstract

Exercise is known to impart transient blood lipid and vascular responses that appear consistent with reduced cardiovascular disease risk. It is unclear how short, disrupted sleep (SDS) modifies post-exercise blood lipid and conduit artery responses to a single episode of exercise. PURPOSE: To determine the influence of a single night of SDS on fasting and postprandial blood lipid and conduit artery responses after high-intensity interval exercise (HIIE). METHODS: Fifteen male participants (age 31.1 + 5.3 yr; weight 83.5 + 11.4 kg; BMI 25.8 + 2.7 kg/m²; VO₂max 49.1 + 8.5 ml/kg/min) completed a non-exercise control trial after 9 to 9.5 hrs of reference sleep (REF), HIIE by treadmill running (90% and 40% of VO₂reserve in 3:2 min ratio) to expend 500 kcals after reference sleep (REF+EX) and HIIE after 3 to 3.5 hrs of short and disrupted sleep (SDS+EX) in a randomized crossover design. Blood samples were obtained by the same technician under standardized conditions just before, immediately after (IPE), 1 hr after exercise (1 HR) and just before a high-fat meal - 1240 kcals (56 g fat; 145 g carbohydrate; 38 g protein) and again 2, 4 and 6hrs after meal ingestion and at equal intervals during REF. Ultrasound measurements of brachial artery flow-mediated dilation (FMD) were obtained in a similar manner just before, 1 hr and 4 hrs after exercise. Total, high-density and low-density lipoprotein cholesterol (HDLC and LDLC) and paraoxonase-1 concentration were measured up to 1 hr post-exercise. Post-prandial triglyceride was measured and area under the curves - total (AUCt) and incremental (AUCi) were calculated. Lipid, lipid-related antioxidant, and FMD responses were analyzed using 3 (condition) by 3 (sample point) repeated measures ANOVAs. AUCt and AUCi were measured using one-way, 3 (condition) repeated measures ANOVAs. RESULTS: HDLC (+6.3%, p = 0.0023) and paraoxonase-1 (+10.8%, pCONCLUSION: Exercise transiently increased brachial artery FMD, fasting HDL cholesterol, and related antioxidant concentrations and reduced triglyceride levels, but did not modify total or incremental triglyceride AUC in response to a post-exercise high-fat meal. Exercise effects on blood lipids and vascular function were not influenced by a single night of short, disrupted sleep.

Recommended Citation

Peterson, Matthew; Papadakis, Zacharias; Forsse, Jeffrey S.; Gutierrez, Fernando; Kyle, Taylor; and Grandjean, Peter (2018) "Metabolic and Vascular Responses to Short, Disrupted Sleep and High-Intensity Interval Exercise in Healthy Men," International Journal of Exercise Science: Conference Proceedings: Vol. 2: Iss. 10, Article 84.
Available at: https://digitalcommons.wku.edu/ijesab/vol2/iss10/84