Brachial Artery FMD Responses to Steady-State Moderate-Intensity and High-Intensity Interval Exercise in Mid-Spectrum Chronic Kidney Disease

Authors

Fernando Gutierrez, Baylor UniversityFollow
Jeffrey S. Forsse, Stephen F. Austin State UniversityFollow
Matthew Peterson, Baylor UniversityFollow
Zacharias Papadakis, Rice UniversityFollow
Peter GrandjeanFollow

Abstract

Brachial artery flow-mediated dilation (FMD) is a nitric oxide-dependent measure of conduit artery endothelial function that is transiently potentiated by moderate-intensity steady state exercise (SSE) in healthy adults. Whether exercise imparts similar effects in adults with Stage 3 or 4 chronic kidney disease (CKD) has not been reported. Moreover, a comparison of SSE and high-intensity interval exercise (HIIE) may add to clinically-relevant findings for improving vascular function in mid-spectrum CKD. PURPOSE: To determine the influence of SSE and a comparable amount of HIIE on post-exercise brachial artery FMD in patients diagnosed with secondary Stage 3 or 4 CKD. METHODS: Twenty participants (n = 10 men; n = 10 women; age 62.0 + 9.9 yr; weight 80.9 + 16.2 kg; body fat 37.3 + 8.5% of weight; VO₂max 19.4 + 4.7 ml/kg/min) completed 30 min of SSE at 65% VO₂reserve or HIIE by treadmill walking (90% and 20% of VO₂reserve in 3:2 min ratio) in a randomized crossover design. Both exercise conditions averaged ~ 65% VO₂reserve. Ultrasound measurements of brachial artery FMD were obtained by the same technician under standardized conditions just before, 1 hr and 24 hrs after exercise. FMD responses were analyzed using 2 (condition) by 3 (sample point) repeated measures ANOVAs. RESULTS: Brachial artery FMD responses were augmented 1 hr after exercise in both exercise conditions (p < 0.005 versus pre-exercise FMD). SSE (pre-exercise = 11.5 + 1.3; 1 hr = 17.2* + 1.8; 24 hr = 14.0* + 1.1%) HIIE (pre-exercise = 12.5 + 1.3; 1 hr = 15.6* + 1.5; 24 hr = 15.8* + 1.2%) CONCLUSION: We report for the first time that brachial artery FMD can be augmented by a single episode of exercise in mid-spectrum CKD. SSE and HIIE, averaging ~65% of VO₂reserve, is equally effective at transiently improving conduit artery vascular function in this clinical population.

Recommended Citation

Gutierrez, Fernando; Forsse, Jeffrey S.; Peterson, Matthew; Papadakis, Zacharias; and Grandjean, Peter (2018) "Brachial Artery FMD Responses to Steady-State Moderate-Intensity and High-Intensity Interval Exercise in Mid-Spectrum Chronic Kidney Disease," International Journal of Exercise Science: Conference Proceedings: Vol. 2: Iss. 10, Article 85.
Available at: https://digitalcommons.wku.edu/ijesab/vol2/iss10/85