The prevalence and severity of hypertension in black individuals are greater than in any other racial/ethnic group in the United States. The arterial baroreflex dynamically regulates blood pressure (BP) on a beat-to-beat basis via alterations in cardiac output and peripheral vascular resistance, and impairments in arterial baroreflex function are well-documented in patients with hypertension. Previous reports suggest that black individuals have a reduced cardiac baroreflex sensitivity compared to their white counterparts. However, the peripheral sympathetic component of the arterial baroreflex has never been examined in young healthy black individuals. PURPOSE: We sought to compare spontaneous sympathetic baroreflex sensitivity between young healthy black and white men. METHODS: Seven healthy black (age: 20 ± 1 years, BMI: 24.3 ± 1.3 kg/m2) and seven healthy white (age: 22 ± 1 years, BMI: 27.0 ± 1.2 kg/m2) men participated in the study. Heart rate (ECG), beat-to-beat BP (finger photoplethysmography) and muscle sympathetic nerve activity (MSNA; peroneal microneurography) were continuously measured during a 20-minute resting period. MSNA was quantified as burst incidence (bursts/100 heartbeats) and averaged over 3-mmHg diastolic BP bins for each individual. The linear relationship between the spontaneous changes in MSNA and diastolic BP was assessed using a weighted linear regression analysis. Sympathetic baroreflex sensitivity was quantified as the slope of MSNA burst incidence to diastolic BP. RESULTS: Heart rate, systolic BP, diastolic BP and mean arterial pressure was not different between the 2 groups (p > 0.05 for all). MSNA burst incidence was also similar between the two groups (black men, 16 ± 2.2 burst/100 heartbeats vs. white men, 21.4 ± 2.0 bursts/100 heartbeats, p = 0.10). The slope of MSNA burst incidence to diastolic BP was significantly lower in black compared to white men (black men, -2.20 ± 0.4 bursts/100 heartbeats/mmHg vs. white men, -3.36 ± 0.3 bursts/100 heartbeats/mmHg, p = 0.03). CONCLUSION: These preliminary data suggest that young healthy black men have a blunted sympathetic baroreflex sensitivity compared to white men.
Nandadeva, Damsara; Young, Benjamin E.; Greaney, Jody L.; and Fadel, Paul J.
"Blunted Spontaneous Sympathetic Baroreflex Sensitivity in Young Healthy Black Men,"
International Journal of Exercise Science: Conference Proceedings: Vol. 2:
12, Article 109.
Available at: https://digitalcommons.wku.edu/ijesab/vol2/iss12/109