Coronary heart disease (CHD) is the world’s leading cause of death, with type 2 diabetes (T2D) increasing that risk ~3-fold. T2D incidence in Hispanics of the Rio Grande Valley (RGV) is >27% vs 9% noted nationwide. Further, having a family history of T2D (FH+) increases risk by ~40%. PURPOSE: To determine if specific aspects of macrovascular function may precede overt hypertension and T2D in FH+ people in the RGV. METHODS: Thirty-three healthy individuals, including 10 FH+ and 23 FH- (26 ± 7; 24 ± 5 yrs respectively), participated in this study. Hemodynamics and large artery function were assessed at rest. One-way ANOVA was used to determine group differences. Pearson correlation was used to determine relationships between significant variables. RESULTS: P1 Height, a measure of forward vascular pressure generated by ventricular contraction, was higher (pCONCLUSIONS: P1 Height is elevated in FH+ individuals and is related to some variables of positive health status, such as triglycerides and lower body fat. More studies are warranted to determine if P1 height is cardioprotective, or a pathophysiological precedent to hypertension.
Sandoval, Kevin I.; Tai, Yu Lun; Figueroa, Gabriel; Nair, Saraswathy; Marupudi, Smaran; Gonzalez, Jimmy; Lopez, Caitlyn; and Russell, Ryan D.
"P1 Height in Hispanics With and Without Family History of Type 2 Diabetes,"
International Journal of Exercise Science: Conference Proceedings: Vol. 2
, Article 72.
Available at: https://digitalcommons.wku.edu/ijesab/vol2/iss13/72