Hispanics of the Rio Grande Valley (RGV) have the highest rates of obesity and type 2 diabetes (T2D) in the country, conditions often associated with cardiovascular disease and increased mortality. We have previously shown that healthy people with a family history of T2D (FH+) display divergent central and peripheral hemodynamic responses postprandially vs those with no family history (FH-). Why these differences exist is unknown. PURPOSE: To identify physiological factors affecting postprandial hemodynamic responses differently between FH+ and FH- groups. METHODS: Thirty-five healthy Hispanic individuals volunteered in this study, including 17 participants with a family history of T2D (FH+, 28 ± 8 yrs) (BMI: 27.5 ± 5 kg/m2) and 18 participants without FH (FH-, 24 ± 5 yrs) (BMI: 25.9 ± 3.2 kg/m2). Hemodynamics were assessed at rest and 60 minutes after consuming a mixed meal challenge (MMC). The MMC consisted of 30g of protein, 5g of fat, and 35g of carbohydrate. A 2x2x2 repeated measures ANOVA was used to evaluate the effects of family history on hemodynamics across conditions and time followed by an ANCOVA to covary for android fat. RESULTS: Overall, there was a significant (pCONCLUSION: Healthy FH+ Hispanics display divergent central and peripheral hemodynamic responses postprandially. However, these differences appear to be driven in large part by android fat storage.



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