Exercise Pressor Response in Hispanic Adults with Family History of Hypertension

Authors

Ashlesha D. Dalve, The University of Texas at AustinFollow
Justo Perez III, University of Texas at AustinFollow
Ruby A. Nyarko, The University of Texas at AustinFollow
Jasdeep Kaur, The University of Texas at AustinFollow

Abstract

Family history of hypertension (FHH), being an unmodifiable risk factor, increases probability of developing hypertension and other cardiovascular diseases. The prevalence of hypertension in Hispanic/Latino (H/La) males is 50.3%, while it is 48.9% in non-Hispanic white (NHW) males and 57.5% in non-Hispanic black (NHB) males. Among adolescents aged 8 to 17, H/La youth has the highest incidence of hypertension as compared to all other races. It is evident that young normotensive adults with positive family history of hypertension (+FHH) exhibit exaggerated exercise pressor response. Additionally, a higher sympathetic activity to cold pressor test (CPT) was found in normotensive NHB adults with +FHH. However, the potential effect of +FHH in H/La population remains unexplored. PURPOSE: In this study we investigated the effect of +FHH on the pressor response during exercise and CPT in H/La adults with +FHH and without family history of hypertension (-FHH). METHODS: In 5 H/La adults with +FHH (age = 24 ± 4 mmHg; BMI = 24 ± 3 kg/m²; MVC = 76 ± 9 kg) and 6 H/La adults with -FHH (age = 21 ± 0.4 years; BMI = 24 ± 1 kg/m²; MVC = 82 ± 10 kg), beat-to-beat blood pressure (finger plethysmography) and heart rate (ECG) were measured at rest and during 2 minutes of static handgrip exercise performed at 30% and 40% of their maximum voluntary contraction (MVC). Muscle metaboreflex was isolated by post exercise ischemia (PEI; supra-systolic cuff (220 mmHg) inflation on the exercising arm) for 2 minutes and 15 seconds. We further investigated the pressor response to CPT, a generalized sympatho-excitatory stimulus, by putting the hand in ice water for 2 minutes. RESULTS: Resting mean arterial pressure (MAP) was not different between groups (+FHH = 78 ± 6 mmHg; -FHH = 79 ± 8 mmHg; p= 0.9). The exercise pressor response at 30% MVC (+FHH = 26 ± 7mmHg; -FHH = 27 ± 8 mmHg; p = 0.9) and 40% (+FHH = 46 ± 8 mmHg; -FHH = 37 ± 13 mmHg; p = 0.3) of MVC static handgrip were not different statistically between the two groups. However, H/La adults with +FHH indicated a trend for augmented pressor response during PEI following handgrip exercise at 40% of MVC (+FHH = 46 ± 4 mmHg; -FHH = 33 ± 10; p = 0.07). The cold pressor response was not different between the two groups (+FHH = 31 ± 6 mmHg; -FHH = 23 ± 15 mmHg; p = 0.36). CONCLUSION: Our preliminary data suggest that Hispanic adults with family history of hypertension exhibit augmented activation of muscle metaboreflex.

Recommended Citation

Dalve, Ashlesha D.; Perez, Justo III; Nyarko, Ruby A.; and Kaur, Jasdeep (2024) "Exercise Pressor Response in Hispanic Adults with Family History of Hypertension," International Journal of Exercise Science: Conference Proceedings: Vol. 2: Iss. 16, Article 103.
Available at: https://digitalcommons.wku.edu/ijesab/vol2/iss16/103