Heart failure (HF) leads to debilitating skeletal muscle dysfunction and atrophy, with exercise tolerance (ET) remaining a crucial indicator of clinical, practical, and mortality-based outcomes. To simulate these comorbidities, monocrotaline (MCT) is a pharmacological agent typically used to aid in replicating experimental models of right ventricle HF. PURPOSE: To investigate the viability of moderate-intensity aerobic training to preserve skeletal muscle function and ameliorate muscle atrophy in MCT-induced HF. METHODS: Thirty 8-week-old male Wistar rats were randomly divided into sedentary (SED) or trained groups (EX; 30min/day treadmill running sessions, 5 days/wk, for 4 weeks) at 60% intensity determined by a maximal endurance test, in which each condition received a single dose of either MCT (60 mg/kg; HF + SED; HF + EX) or equivalent saline solution (SS + SED; SS + EX). Before and after exercise training, in vivo plantar flexor maximal isometric contractions were performed to assess muscle function at 10, 60, and 120Hz. ET was assessed using a maximal endurance test before and after exercise training, respectively. Separate two-way ANOVAs were used to evaluate significance at a level of pRESULTS: Both HF + SED (p=.0016; 10.7±3min) and HF + EX (p.05). Similar differences were also found in the mass of gastrocnemius-soleus complex, wherein both HF + SED (p=.0047; 2.13±0.32g) and HF + EX (p=.0461; 2.11±0.29g) saw diminished muscle mass when compared to their parallel controls (2.66±0.15g and 2.52±0.25g for SS + SED and SS + EX, respectively). CONCLUSION: Although HF animals saw a significant reduction in skeletal muscle mass and concomitant function, endurance training remains a potentially therapeutic intervention by providing a partial protective effect on overall skeletal muscle health.



To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.