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Abstract

Skeletal muscle hypertrophy is a key adaptation to resistance training, yet the time when measurable growth occurs remains unknown in previously untrained women. Evaluating hypertrophic changes over a short intervention period has important implication for training adaptations and program design. PURPOSE: The purpose of this study is to quantify the time course of muscle size cross sectional area (CSA) and morphological adaptations of the rectus femoris (RF) following 8-weeks of resistance training in previously untrained, college-aged women. METHODS: Twenty-two healthy, untrained female participants (age, 18-35, BMI, 22.65±2.61 kg/m2) were randomized to either an 8-week resistance-training group (TRAIN) or control group (CON). The TRAIN group completed a twice weekly, progressive lower-body program (flywheel deadlift, barbell front squat, leg press, and leg extension). Progression of the loads corresponded to the maximum load that each participant could perform for 4 sets of 8-12 repetitions. If the prescribed loads and repetitions were completed, ~2.3kg were added for the subsequent training session. Both groups completed 6 laboratory testing sessions, separated by 2 weeks. Every testing session included ultrasound imaging of the rectus femoris along with body composition and neuromuscular assessments. Images at 50% of the rectus femoris were taken with brightness-mode ultrasound and an open-source software (ImageJ) was utilized to analyze the CSA of the muscle. A linear mixed effect model was employed with group, time (PRE vs POST), and their interaction as fixed effects. Random effects included random intercepts for individual participants. RESULTS: Outcomes indicated a significant increase in the RF CSA in the TRAIN group but not CON, yielding a significant group by time interaction (B = 58.89 cm2, t = 2.75, p < 0.05). CONCLUSION: Detectable size adaptations of the RF occurred within just 8 weeks of resistance training in previously untrained women. These findings refine expectations for early muscular adaptations and reinforce the effectiveness of short-term resistance training for initiating measurable muscle growth in novice female populations.

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