•  
  •  
 

Abstract

The Correlation of Physical Activity and Body Composition in Inbred Mice.

Analisa .M Jimenez*; David .P Ferguson MS RCEP; J. Timothy Lightfoot, PhD FACSM RCEPCES

I would like to participate in the undergraduate category.

Biology of Physical Activity Lab, Texas A&M University, College Station TX, 77843-4243

Obesity is a growing epidemic related to physical inactivity, cardiovascular disease, and Type II diabetes. In smaller mouse cohorts, there has been no association reported between physical activity and body composition indices. The purpose of this experiment was to determine if there was a correlation between the physical activity level and body composition in a large cohort of inbred mouse strains. Using a GE Lunar Piximus (Madison, WI), body composition of 420 mice across 17 strains was analyzed for association with percent body fat, lean mass, and fat mass. Activity data using a running wheel had previously been measured in each of these mice. Pearson correlations were determined using the indices of body composition and physical activity level with alpha <0.05 set a priori. There was a significant (p=0.013) correlation (r2 = 0.87) between mouse strain and fat mass (p < 0.05). Additionally, there trends for lean mass (p=0.053) and total body weight (p=0.056) to be correlated to mouse strain. There was not a significance association between the body composition characteristics (fat mass (p=0.013), lean mass (p=0.053), and percent body fat (p=0.068)) and physical activity in the mice. From these results, we have supported previous literature showing a genetic predisposition for fat mass within each mouse strain. Further, the lack of significant relationship between body composition and daily activity is not surprising given previous published data in smaller mouse cohorts. Our data support previous suggestions that body composition and the inherent drive to be active are independent of each other.

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.