•  
  •  
 

HABITUAL PHYSICAL ACTIVITY, DISEASE SEVERITY, AND QUALITY OF LIFE IN PATIENTS WITH IDIOPATHIC PULMONARY FIBROSIS

Abstract

E.K. Traylor, C.E. Child, M.B. Brown

Universtity of Washington, Seattle, WA

Idiopathic Pulmonary Fibrosis (IPF) is a progressive lung disease characterized by fibrosis of the lung interstitium resulting in impaired gas exchange. This study characterizes relationships between habitual physical activity, pulmonary function, dyspnea, quality of life, and submaximal exercise tolerance in patients with IPF. METHODS: Adults with IPF enrolled in a randomized controlled trial (NCT04838275) were issued a wearable activity tracker (Fitbit Charge 4) and reported dyspnea levels for a 4-week period prior to randomization to receive an exercise intervention or remote monitoring alone. Subjects completed pulmonary function tests (PFTs), 6-minute walk test (6MWT), and the St. George’s Respiratory Questionnaire for IPF (SGRQ-I) at 4 weeks. Relationships were analyzed using Pearson correlations. RESULTS: Eight subjects were included in this preliminary analysis (Table 1). The SGRQ-I Total score correlated with dyspnea (r=0.75, p=0.031) and submaximal exercise tolerance (%pred 6MWT distance) (r=-0.76, p=0.029). Two SGRQ-I domains individually correlated with 6MWT distance (Symptoms: r=-0.78, p=0.023; Activities: r=-0.85, p=0.0081) and dyspnea (Activities: r=0.79, p=0.019). Physical activity measures did not relate to quality of life, dyspnea, 6MWT distance, or %pred FEV1 and FVC, but did correlate with diffusion capacity (%pred DLCO) (r=0.85, p=0.0070). CONCLUSION: In patients with IPF, habitual physical activity behaviors may be related to disease severity, as measured by DLCO. The Symptoms and Activities domains of the SGRQ-I had strong negative correlations with 6MWT distance, suggesting that reductions in submaximal exercise tolerance negatively impact IPF-specific quality of life.

(AWARD WINNER)

Additional Files
Table 1.docx (13 kB)
Table 1

This document is currently not available here.

Share

COinS