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ASSOCIATIONS OF SEDENTARY BEHAVIOR AND SCREEN TIME WITH MARKERS OF INFLAMMATION AND INSULIN RESISTANCE

Abstract

G.H Coughlin1, M. Antush2,C.A Vella2

1University of Washington School of Medicine, Seattle, WA, USA

2University of Idaho, Moscow, ID, USA

Sedentary behavior (SB) has been linked to individual risk factors of cardiometabolic disease (CMD) such as inflammation and insulin resistance. However, the associations reported have been limited to select biomarkers in specific populations with inconsistent results. PURPOSE: To determine associations of sedentary behaviors with multiple biomarkers of inflammation and insulin resistance in adults. METHODS: Seventy-eight men and women (mean±SD 52.0±10.8 y) self-reported domain-specific SB using the Sedentary Behavior Questionnaire and sitting time and moderate-to-vigorous physical activity (MVPA) using the International Physical Activity Questionnaire short form. Body fat percentage (BF%) was assessed using multi-frequency bioelectrical impedance. A fasting blood draw assessed glucose, insulin, C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), leptin, and adiponectin. Adiponectin-leptin ratio (ALR), homeostatic model assessment of insulin resistance (HOMA-IR) and beta-cell function (HOMA-β) were calculated. Multivariable linear regression analyses, controlling for sex, age, MVPA, and BF%, were used to assess associations of SB with biomarkers of inflammation and insulin resistance. RESULTS: After adjustment for sex, age, and MVPA, total SB (7.5±2.5 h/day) was positively associated with leptin, insulin, HOMA-IR, HOMA-β (Standardized Beta (β) range 0.21-0.32) and negatively associated with ALR (β=-0.24, p<0.05 for all). Somewhat similarly, total sitting time (7.2±2.9 h/day) was associated with TNF-α (β=0.22) and ALR (β=-0.26). These associations were attenuated to non-significance after adjustment for BF%. Leisure screen time was detrimentally associated with IL-6 (β=0.24), leptin (β=0.21), ALR (β=-0.22), insulin (β=0.37), HOMA-IR (β=0.37), and HOMA-β (β=0.34), controlling for sex, age, and MVPA (p<0.05 for all). Only the associations with insulin (β = 0.26), HOMA-IR (β =0.26), and HOMA-β (β =0.23) remained significant after further controlling BF% (p<0.05). CONCLUSION: Self-reported SB is associated with biomarkers of inflammation and insulin resistance, independent of MVPA but not BF%. These findings suggest that SB may contribute to risk of CMD in adults.

*Research was partially funded by a small grant from InBody USA.

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