EXAMINATION OF THE MONOAMINE OXIDASE A GENE PROMOTER ON MOTIVATION TO EXERCISE AND LEVELS OF VOLUNTARY PHYSICAL ACTIVITY
PURPOSE: The purpose of this study is to examine the genetic basis underlying voluntary exercise. Monoamine oxidase A (MAO-A) is an enzyme that acts on monoamine neurotransmitters, such as dopamine, to cause inactivation. There are several polymorphisms in the promoter region of the MAO-A gene and these variations change transcriptional activity and the amount of MAO-A produced, leading to alterations in available dopamine levels. Interestingly, polymorphisms in MAO-A have been associated recently with physical activity level. This study sought to determine whether there is an association between motivation to exercise, levels of voluntary physical activity and monoamine oxidase A (MAO-A) gene polymorphisms. METHODS: Seventy-one participants (age 18-24 years, 13 males & 58 females) completed the Behavioral Regulation in Exercise Questionaire-2 (BREQ-2) to assess their motivation to exercise and the International Physical Activity Questionnaire (IPAQ) to assess their level of physical activity. DNA was collected and isolated from a cheek cell sample. The MAO-A genotype was identified using PCR with gene specific primers. MAO-A 3/3 and 4/4 genotype individuals were used for analysis. A random subsample will be re-genotyped in order to confirm our results. RESULTS: External motivation to exercise was significantly higher (p < 0.01) in the high transcription 4/4 genotype (ave 1.17 ± 0.7) compared to the low transcription 3/3 genotype (ave 0.42 ± 0.5). Internal motivation to exercise was not different between genotypes. Body mass index and weekly MET minutes estimated by IPAQ were also comparable between genotypes. CONCLUSION: The results suggest a polymorphism in this monoamine pathway may play a role in increasing sensitivity to external factors that motivate individuals to exercise.
Kinney, E.; Coste, S.; and Reinke, C.
"EXAMINATION OF THE MONOAMINE OXIDASE A GENE PROMOTER ON MOTIVATION TO EXERCISE AND LEVELS OF VOLUNTARY PHYSICAL ACTIVITY,"
International Journal of Exercise Science: Conference Proceedings: Vol. 8
, Article 50.
Available at: https://digitalcommons.wku.edu/ijesab/vol8/iss5/50