Publication Date
12-2011
Advisor(s) - Committee Chair
Dr. Kevin Williams (Director), Dr. Stuart Burris, Dr. Bangbo Yan
Degree Program
Department of Chemistry
Degree Type
Master of Science
Abstract
Chemotherapy is the first line of treatment used in cancer. Chemotherapy drugs such as cisplatin, carboplatin and oxaliplatin are used in treatment. Cisplatin enters the cell through copper transporter CTR1 by passive diffusion and bind to DNA and proteins. Cisplatin is found to inhibit several enzymes targeting cysteine, histidine and methionine residues, which are expected to be responsible for its anticancer activity. A better understanding of how the size and shape and leaving ligands of platinum complexes affect cysteine protease, papain enzyme are studied. This could give new ways to optimize anticancer activity. The activity of papain enzyme was measured on UV-Visible spectroscopy. The inhibition profile of papain with different platinum (II) complexes, and with different combinations was studied.
Disciplines
Chemistry | Enzymes and Coenzymes | Medicinal-Pharmaceutical Chemistry
Recommended Citation
Rapolu, Chaitanya, "Inhibition of Cysteine Protease by Platinum (II) Diamine Complexes" (2011). Masters Theses & Specialist Projects. Paper 1137.
https://digitalcommons.wku.edu/theses/1137