Publication Date

8-2013

Advisor(s) - Committee Chair

Quentin Lineberry (Director), Yan Cao, Stuart Burris

Degree Program

Department of Chemistry

Degree Type

Master of Science

Abstract

The main objective of this work is to investigate the ionic conductivity of the drugs under certain conditions and also to compare the ionic conductivities of drugs determined by single surface sensors and parallel plate sensors. The ionic conductivity of various materials at their pre-melt and melt states are studied in order to further study a recently discovered phenomenon. Polar solids like Lidocaine, Ketoconazole, Procainamide and Nifedipine were examined in this study. Experimental studies show an increase in ionic conductivity in both pre-melt (20 -30 °C below melting temperature) and melt transition regions. Results of ionic conductivity of both parallel plate and single surface sensor at different frequencies are compared. At 1000 Hz, all the samples show an increase in ionic conductivity with both parallel plate and single surface sensor, but at 0.1 Hz frequency, no increase in ionic conductivity is observed with parallel plate sensor except for Nifedipine.

Disciplines

Chemicals and Drugs | Chemistry | Inorganic Chemistry | Medicinal-Pharmaceutical Chemistry

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