Advisor(s) - Committee Chair
Dr. Kevin Williams (Director), Dr. Cathleen J. Webb, Dr. Lester Pesterfield
Department of Chemistry
Master of Science
Water soluble platinum complexes are a recent area of emphasis of cisplatin chemistry. The water soluble complexes could have a reduced toxicity compared with cisplatin. Oxaliplatin, which has an oxalate leaving group, has previously been shown to have less nephro-toxicity and higher water solubility than cisplatin. [Pt(en)(oxalate)] (en = ethylenediamine) has been prepared from Pt(en)Cl2 and silver oxalate. This complex has been reacted with methionine and N-acetylmethionine at different molar ratios. At high Pt: methionine ratios, chelates with the sulfur and nitrogen atoms of the methionine are dominant; at lower Pt: methionine ratios, a bis-methionine product is formed. The en ligand is displaced by methionine but not N-acetylmethionine.
Cancer Biology | Inorganic Chemistry | Medicinal-Pharmaceutical Chemistry
Liao, Yueh Ying, "The Reaction of a Water Soluble Platinum Compound with Methionine and Derivatives" (2010). Masters Theses & Specialist Projects. Paper 153.