Advisor(s) - Committee Chair
Thomas P. Coohill, Larry Elliott, Fernando Morgado
Department of Biology
Master of Science
The effect of ultraviolet (UV) radiation in the wavelength region 230 nm to 302 nm on the ability of an irradiated mammalian cell to reactivate UV-irradiated mammalian virus was tests. An action spectrum for radiation enhanced reactivation (RER) Is presented. The shape of the action spectrum points to a combined nucleic acid protein target for UV radiation effects on this cellular parameter. An analysis of the results of others involving the biochemical and photobiological events involved in the RER does not allow the identification of the macromolecule which is the major contributor to this effect. Studies involving an analogous phenomenon in bacteria (Weigle reactivation) imply that RER and WR may involve similar mechanisms.
Biology | Diseases | Immunology and Infectious Disease | Medicine and Health Sciences | Virus Diseases
James, Leslie C., "The Wavelength Dependence of Ultraviolet Enhanced Reactivation in A Mammalian Cell-Virus System" (1978). Masters Theses & Specialist Projects. Paper 1705.