Advisor(s) - Committee Chair
Larry Gleason, Hugh Puckett, Donald Bailey
Department of Biology
Master of Science
The presence of lesions in the liver of mice is associated with the infection of these mice with the common bile duct -dwelling cestode, Hymenolepis microstoma. Lesions develop even though there is no direct contact between the cestodes and the liver. It was found in this investigation that administration to mice of Tyrode's solution, in which cestodes had been incubated for 24 hr, resulted in liver lesions comparable to those observed in normal infections. The administration of the causative substance by either per os intubation or intraperitoneal injection produced similar lesions. Further studies revealed that the active lesion - causing substance was isolated in a lipid extract of the metabolic by-products. It was also determined that the active material had a molecular weight of less than 10,000.
Biology | Life Sciences
Simpson, Gary, "Lesion Formation in the Liver of Mice Caused by metabolic By-Products of Hymenolepsis Microstoma" (1974). Masters Theses & Specialist Projects. Paper 2851.