Laura Wells

Publication Date


Advisor(s) - Committee Chair

Wei-Ping Pan, John Riley, Thandi Buthelezi


Access granted to WKU students, faculty and staff only.

After an extensive unsuccessful search for the author, this thesis is considered an orphan work, which may be protected by copyright. The inclusion of this orphan work on TopScholar does not guarantee that that orphan work may be used for any purpose and any use of the orphan work may subject the user to a claim of copyright infringement. The reproduction of this work is made by WKU without any purpose of direct or indirect commercial advantage and is made for purposes of preservation and research.

See also WKU Archives - Authorization for Use of Thesis, Special Project & Dissertation

Degree Program

Department of Chemistry

Degree Type

Master of Science


Thermoanalytical methods have proven to be useful in all steps of the pharmaceutical development process and in quality control of product. These methods have become increasingly important in the solution of an assortment of scientific problems in the pharmaceutical industry. Careful attention must be paid to safety, quality, purity, and stability of a pharmaceutical formulation to ensure proper performance. Therefore, analysis of the fully formulated pharmaceutical tablet is critical in gaining an understanding of the pharmaceutical behavior.

Nine pharmaceuticals of various functionalities were evaluated using Differential Scanning Calorimetry (DSC) to characterize the “fingerprint” pattern and Oxidation Onset Temperature (OOT) of each pharmaceutical. In addition, the OOT method was evaluated with regard to effectiveness as a measure of relative pharmaceutical stability. Thermogravimetric Analysis (TGA) and Fourier Transform-Infrared Spectroscopy (FTIR) were used in conjunction with DSC results to characterize physical and chemical changes in the pharmaceutical sample as a function of temperature change.


Chemistry | Physical Sciences and Mathematics