The Reaction of Methionine with a Non-C2-Symmetrical Platinum (II) Diamine Compound

Department

Chemistry

Authors

Nilesh Sahi, Western Kentucky UniversityFollow

Document Type

Thesis

Abstract

The research that we have conducted has allowed us to discover that the amino acids, methionine (Met) and N-acetyl methionine (N-AcMet), will react in a 1:1 and 1:2 molar ratio with platinum complexes containing bulky diamine ligands. Previous research has allowed us to gain a plethora of information on the experimentation and results of specific bulky diamine ligands such as N,N,N',N'-tetramethylethylenediamine and N,N-diethylethylenediamine. In the current study, we have investigated the bulky diamine ligand of N,N-dimethylethylenediamine, or Me₂en. With our focus on the bulk of the Me₂en ligand, we have been able to synthesize a platinum complex in Pt(Me₂en)Cl₂ and react it with Met and N-AcMet. Through analysis using NMR spectroscopy and LC/MS, we have been able to observe the formation of a S,O-chelate formation in the reaction of the platinum complex with N-AcMet. This implies that a second methionine is not able to coordinate to the position that is cis to the bulk.

Advisor(s) or Committee Chair

Dr. Kevin Williams

Disciplines

Chemicals and Drugs | Chemistry | Medicinal Chemistry and Pharmaceutics | Organic Chemicals | Organic Chemistry

Recommended Citation

Sahi, Nilesh, "The Reaction of Methionine with a Non-C2-Symmetrical Platinum (II) Diamine Compound" (2012). Mahurin Honors College Capstone Experience/Thesis Projects. Paper 357.
https://digitalcommons.wku.edu/stu_hon_theses/357