Oxaliplatin is a third generation anticancer drug that has proven to be successful in fighting ovarian and testicular cancer. We are interested in determining how oxaliplatin and oxaliplatin derivatives interact with proteins, as well as how that interaction is affected by the size and shape of these platinum compounds. We have synthesized oxaliplatin as it is used in cancer treatment, as well as similar platinum compounds with the same diaminocyclohexane ligand as oxaliplatin but with additional bulk added to the nitrogen atoms. We are reacting oxaliplatin with key amino acids, including methionine, and will be comparing the kinetics of this reaction, as well as the adducts formed in the reaction, with the bulkier oxaliplatin derivative.
Advisor(s) or Committee Chair
Dr. Kevin Williams
Biology, general | Cancer Biology | Chemicals and Drugs | Chemistry | Organic Chemistry | Other Chemicals and Drugs
Poynter, Amy, "Oxaliplatin and Oxaliplatin Derivatives: Synthesis, Characterization, and Reactivity with Biologically Relevant Ligands" (2012). Honors College Capstone Experience/Thesis Projects. Paper 366.
Available for download on Sunday, May 25, 2014