Publication Date
12-2023
Advisor(s) - Committee Chair
Ali Oguz Er, Ivan Novikov, Lawrence Hill
Degree Program
Department of Physics and Astronomy
Degree Type
Master of Science
Abstract
Although biomedical implant technology is very advanced, there are still caveats in terms of biocompatibility properties because metals are inert to biological processes such as osseointegration, cell growth, and cell adhesion. This results in statistically significant complications and opens rooms for improvements. Among many techniques to improve this problem, coating the metal surface with biologically functional materials has resulted in the best performances. Hydroxyapatite (HAP), Ca₁₀(PO₄)₆(OH)₂, is the most stable form of calcium phosphates in human body environment and is functional in key processes such as ion exchange, osteoblast (bone cells) formation, bone remodeling, and etc. In the last several decades, hundreds of research projects have been directed to research their roles in bioactivity, drug delivery, and tissue engineering areas. In this thesis, coating the implant surfaces with HAP via pulsed laser deposition technique is studied. Performance of the coatings depends on several aspects. Successful coating should be mechanically non-dissolvable in human body environment, biologically active, and adherent to the implant surface. These requirements led to several key correlations with crystallinity and Ca/P ratio of HAP along with other non-trivial properties. Therefore, structural properties and surface morphologies are important aspects that define the interaction routes. This work studied how to obtain crystalline HAP via pulsed laser deposition and revealed important findings about the cautions to be taken at elevated temperatures. This thesis is structured as follows. First, biomedical implant industry and the need for hydroxyapatite coatings are introduced. Then, the explanation for the reasons why pulsed laser deposition offers an excellent solution for this problem is provided. Finally, the structural and bioactivity assessment results are presented and discussed.
Disciplines
Engineering | Mathematics | Medicine and Health Sciences | Physical Sciences and Mathematics
Recommended Citation
Kylchbekov, Salizhan, "Bioactivity and Structural Properties of Hydroxyapatite on Ti6A|4V and Si(100) Surfaces by Pulsed Laser Deposition" (2023). Masters Theses & Specialist Projects. Paper 3692.
https://digitalcommons.wku.edu/theses/3692