The research that we have conducted has allowed us to discover that the amino acids, methionine (Met) and N-acetyl methionine (N-AcMet), will react in a 1:1 and 1:2 molar ratio with platinum complexes containing bulky diamine ligands. Previous research has allowed us to gain a plethora of information on the experimentation and results of specific bulky diamine ligands such as N,N,N',N'-tetramethylethylenediamine and N,N-diethylethylenediamine. In the current study, we have investigated the bulky diamine ligand of N,N-dimethylethylenediamine, or Me2en. With our focus on the bulk of the Me2en ligand, we have been able to synthesize a platinum complex in Pt(Me2en)Cl2 and react it with Met and N-AcMet. Through analysis using NMR spectroscopy and LC/MS, we have been able to observe the formation of a S,O-chelate formation in the reaction of the platinum complex with N-AcMet. This implies that a second methionine is not able to coordinate to the position that is cis to the bulk.
Advisor(s) or Committee Chair
Dr. Kevin Williams
Chemicals and Drugs | Chemistry | Medicinal Chemistry and Pharmaceutics | Organic Chemicals | Organic Chemistry
Sahi, Nilesh, "The Reaction of Methionine with a Non-C2-Symmetrical Platinum (II) Diamine Compound" (2012). Mahurin Honors College Capstone Experience/Thesis Projects. Paper 357.