Mahurin Honors College Capstone Experience/Thesis Projects
Biomass Assisted Synthesis of Antibacterial Gold Nanoparticles and Commentary on its Future Potential and Applications in Medicine
Additional Departmental Affiliation
Xylose is a natural monosaccharide found in biomass such as straw, pecan shells, cottonseed hulls, and corncobs. Using this monosaccharide, we report the green synthesis and characterization of biocompatible, biodegradable xylose encapsulated gold nanoparticles (Xyl-GNPs) with potential antibacterial activity. GNPs were synthesized using the bioreduction property of xylose on the chloroaurate anions in an aqueous solution at room temperature and at atmospheric pressure. The characterization of synthesized GNPs was examined by UV-vis spectroscopy; transmission electron microscopy (TEM), energy-dispersive x-ray spectroscopy (EDS) and fourier transform infrared spectroscopy (FTIR). Results indicate that the particles were stable; near spherical in shape with an average diameter of 15 ± 5 nm. Microbiological assay results showed the concentration dependent antibacterial activity of these particles against Escherichia coli. Thus the facile, environmentally friendly Xyl-GNPs have potential application in the biomedical field, particularly in the development of alternative antibacterial agents.
Advisor(s) or Committee Chair
Dr. Rajalingam Dakshinamurthy
Alternative and Complementary Medicine | Biological Factors | Biology | Biotechnology | Chemicals and Drugs | Chemistry | Medical Sciences | Other Medicine and Health Sciences | Pharmacy and Pharmaceutical Sciences
Willis, Chad, "Biomass Assisted Synthesis of Antibacterial Gold Nanoparticles and Commentary on its Future Potential and Applications in Medicine" (2012). Mahurin Honors College Capstone Experience/Thesis Projects. Paper 368.
Alternative and Complementary Medicine Commons, Biological Factors Commons, Biology Commons, Biotechnology Commons, Chemistry Commons, Medical Sciences Commons, Other Medicine and Health Sciences Commons, Pharmacy and Pharmaceutical Sciences Commons